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5541 Pathology

A 45-year-old man presents with weakness and wasting of the muscles of his right hand for 8 months. Physical examination shows fasciculations of the hand. The patient’s speech is impaired, and 6 years later, he dies of respiratory insufficiency. Autopsy shows atrophy of ventral roots in the spinal cord. Which of the following is the most likely diagnosis?

AAmyotrophic lateral sclerosis
BGerstman Straussler-Scheinker disease
CHuntington disease
DMultiple infarct dementia
Pathology
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