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4666 Pathology

A family suspected of child abuse because one of their children has had multiple fractures consults an ohopedic specialist at a children’s hospital. The specialist examines the child, who is now 5 years old, and notes that the child has blue-tinged sclera, hearing loss, and small, slightly blue, misshapen teeth. Radiologic studies confirm the presence of numerous fractures of various ages. No significant degree of bruising is seen over sites of recent fracture. The disease this child most likely has is related to abnormal metabolism involving which of the following substances?

ACollagen
BGlycogen
CMucopolysaccharides
DPurines
Pathology
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4671 Pathology

A 42 -year old man was referred with a 2 week history of fever weakness and bleeding gum. Peripherial smear showed pancytopenia. The bone marrow examination revelaed 26% blasts frequently exhibiting Auer rods and mature myeloid cells. An occasional neutrophil with pseudo Pelger-Huet anomaly was also noted : Which of the following cytochemical stains is most likely to be positive –

AAcid phosphatase
BNon specific esterase
CMyeloperoxidase
DToluidine blue.
Pathology
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