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4411 Pathology

A 30-year-old man presents with a 3-week history of fatigue, occasional fever, yellow skin and sclerae, tenderness below the right costal margin, and dark urine. Physical examination reveals jaundice and mild hepatomegaly. Laboratory studies show elevated serum levels of bilirubin, decreased albumin, and prolonged prothrombin time. Serologic tests disclose antibodies to hepatitis C virus. Which of the following tests is the most accurate method for assessing the extent of liver disease in this patient?

ALiver biopsy
BSerum alkaline phosphatase
CSerum ammonia
DSerum immunoglobulins
Pathology
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4413 Pathology

A 67-year-old male presents with increasing fatigue and is found to be anemic. Physical examination reveals a hard 1-cm nodule in the left lobe of the prostate. The prostatic-specific antigen (PSA) level is found to be elevated. Examination of the peripheral blood reveals an occasional myelocyte. The erythrocytes are mainly normochromic and normocytic, and teardrop RBCs are not found. There are however, about two nucleated red blood cells per 100 white cells. What is the best diagnosis for this patient’s anemia?

AFanconi's anemia
BMicroangiopathic hemolytic anemia
CMyelophthisic anemia
DAutoimmune hemolytic anemia
Pathology
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4417 Pathology

A person taking an oral sulfonamide is found to have a markedly decreased peripheral blood neutrophil count, but the numbers of platelets and erythrocytes are normal. If the peripheral neutropenia is the result of antineutrophil antibodies being produced in response to taking the sulfonamide, then this patient would be expected to have

AAn atrophic spleen
BDecreased vitamin B12 levels
CHypoplasia of the bone marrow myeloid series
DHyperplasia of the bone marrow myeloid series
Pathology
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