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3856 Pathology

A 77-year-old man has a lesion on the right side of his face that has enlarged slowly over the past 5 years. On examination, the 3-cm lesion has irregular borders, irregular brown to black pigmentation, and a central 2-mm raised blue-black nodule. The lesion is resected and microscopically shows radial growth of large round malignant cells, some isolated and others in nests in the epidermis and superficial papillary dermis. The cells have prominent red nucleoli and dust-like cytoplasmic pigment. Which of the following mutated genes is most likely to be present in the skin lesion of this man?

AATM
BBRAF
CNF1
DTYR
Pathology
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