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3757 Pathology

A 4-year-old girl presents with swelling of the legs and ankles. Physical examination reveals pitting edema of the lower extremities. Urinalysis show 2+ proteinuria. The urinary sediment contains no inflammatory cells or red blood cells. Serum levels of BUN and creatinine are normal. The patient recovers completely after a course of corticosteroids. For the patient, electron microscopy of a renal biopsy specimen prior to treatment would most likely demonstrate which of the following abnormalities?

ADuplication of capillary basement membranes
BElectron-dense immune deposits in the capillary basement membranes
CElectron-dense immune deposits in the mesangium
DFusion of podocyte foot processes
Pathology
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3760 Pathology

A healthy, 44-year-old woman, G2, P1, has a screening ultrasound at 18 weeks’ gestation that shows no fetal anomalies. There is decreased fetal movement at 32 weeks’ gestation, and ultrasound shows fetal growth restriction with relative sparing of the fetal head. The placenta appears normally positioned in the lateral fundus, but appears small, and the amniotic fluid index is reduced. Maternal blood pressure is normal. Which of the following conditions is most likely to be present?

AUteroplacental insufficiency
BCongenital Treponema pallidum infection
CGalactosemia
DPreeclampsia
Pathology
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