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3631 Pathology

A 40-year-old man has had an increasing cough with hemoptysis for 2 weeks. He has never smoked and is in very good health. On physical examination, his temperature is 38.2deg C. A chest radiograph shows an area of consolidation in the right upper lobe. His condition improves with antibiotic therapy; however, the cough and hemoptysis persist for 2 more weeks. Chest CT scan now shows right upper lung atelectasis. Bronchoscopic examination shows a tan, circumscribed obstructive mass filling a right upper lobe bronchus. Which of the following neoplasms is most likely to produce these findings?

AAdenocarcinoma
BCarcinoid tumor
CHamartoma
DKaposi sarcoma
Pathology
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3633 Pathology

An experiment studies early atheroma development. Lipid streaks on arterial walls are examined microscopically and biochemically to determine their cellular and chemical constituents and the factors promoting their formation. Early lesions show increased attachment of monocytes to the endothelium. The monocytes migrate subendothelially and become macrophages; these macrophages transform themselves into foam cells. Which of the following substances is most likely to be responsible for the transformation of macrophages?

AC-reactive protein
BHomocysteine
CLp(a)
DOxidized LDL
Pathology
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