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3575 Pathology

A 12-year-old boy develops fever, accompanied by occasional headaches, malaise, fatigue, and nausea a month after being bitten by a dog. One day later, he experiences episodes of rigidity, hallucinations, breath-holding, and difficulty swallowing because of uncontrollable oral secretions. Dr. Louis Pasteur is consulted. He writes: “The death of this child appearing to be inevitable, I decided, not without lively and sore anxiety, as may well be believed, to try ……. the method which I had found constantly successful with dogs. Consequently, 60 hours after the bites was inoculated under a fold of skin with half a syringeful of the spinal cord of a rabbit. In the following days, fresh inoculations were made. I thus made 13 inoculations.” The boy survives. Which of the following histologic findings in the brain of the dog is most likely to be present?

AMultinucleate giant cells
BNegri bodies
CPerivascular lymphocytes
DPseudocysts with bradyzoites
Pathology
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