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3310 Pathology

During a laboratory exercise on coagulation testing, a 23-year-old medical student is found to have a prolonged bleeding time. She has had a long history of “easy bleeding,” with frequent bleeding of the gums, epistaxis, cutaneous bleeding, and menorrhagia. Fuher testing revealed a deficiency of Von Willebrand factor. Which of the following thrombogenic processes involving platelets is most directly impaired?

AAdhesion
BConformational change with activation of phospholipid surface
CFormation of fibrinogen bridges
DRelease reaction
Pathology
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