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3172 Pathology

A 22-year-old man complains about his inability to conceive a child. On physical examination, the patient is noted to be tall (6 ft, 5 in) and exhibits gynecomastia and testicular atrophy. Laboratory studies demonstrate increased serum levels of follicle-stimulating hormone. Cytogenetic studies reveal a chromosomal abnormality. What is the most common cause of this patient’s chromosomal abnormality?

AExpansion of a trinucleotide repeat
BIsochromosome formation
CMeiotic nondisjunction
DNonreciprocal translocation
Pathology
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