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2240 Pathology

In a study of inheritance of the cystic fibrosis gene (CFTR), the genetic mutations in carriers and affected individuals are documented. Based on these findings, investigators determine that there is no simple screening test to detect all carriers of mutations of the CFTR gene. Which of the following is most likely to be the greatest limitation to development of a screening test for CFTR mutations?

ABoth copies of the gene must be abnormal for detection
BFluorescence in situ hybridization is labor-intensive and expensive
CFrequency of mutations among ethnic groups limits sensitivity
DLess than 1 individual in 10,000 is a heterozygote
Pathology
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