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1987 Pathology

A 40-year-old man presents with muscle weakness. He cannot open his hand for a handshake and cannot extend his arm after flexing it. On physical examination, he has marked atrophy of leg and arm muscles, ptosis, and a fixed facial expression. There is testicular atrophy. Laboratory studies demonstrate mild diabetes. A muscle biopsy reveals atrophy of type I fibers, hyperophy of type II fibers, and numerous fibers with centrally located nuclei. Which of the following is the most likely diagnosis?

ADermatomyositis
BDuchenne muscular dystrophy
CNemaline myopathy
DMyotonic dystrophy
Pathology
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