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1969 Pathology

A 36-year-old man from China presents with increasing fatigue. He has a 3-year history of tuberculosis, and CBC shows a mild microcytic anemia. Blood work-up demonstrates low serum iron, low iron-binding capacity, and increased serum ferritin. The pathogenesis of anemia in this patient is most likely caused by which of the following mechanisms?

AClonal stem cell defect
BHypoxemia
CImpaired utilization of iron from storage sites
DSynthesis of structurally abnormal globin chains
Pathology
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