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1769 Pathology

A 50-year-old woman presents with acute right flank pain of 72 hours in duration. Her temperature is 37degC, BP-140/85 mm Hg, and pulse 85/minute. A CBC is normal. Urinalysis reveals hematuria and urine cultures are negative. Imaging studies show stones in the right renal pelvis and ureter. This patient’s condition may be associated with which of the following endocrine disorders?

AConn syndrome
BCushing syndrome
CHyperparathyroidism
DHypehyroidism
Pathology
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1770 Pathology

A 25-year-old man complains of eruptions of blisters on his scalp and inner surface of the groin and in his mouth. The blisters rupture easily and leave large crusted areas. Histologically, the lesions show separation of the stratum spinosum from the basal layer. The results of direct immunofluorescence microscopy for IgG are shown. Which of the following proteins is targeted by IgG autoantibody in the skin of this patient?

ACollagen type IV
BDesmoglein-3
CE-cadherin
DFibronectin
Pathology
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1773 Pathology

During a year-long training program, a 23-year-old female air force officer falls in class rank from first place to last place. She has also noted a lower pitch to her voice and coarsening of her hair, along with an increased tendency toward weight gain, menorrhagia, and increasing intolerance to cold. Which of the following laboratory abnormalities is expected?

AIncreased serum free T4
BIncreased serum T3 resin uptake
CIncreased saturation of thyroid hormone-binding sites on TBG
DIncreased serum TSH
Pathology
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