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1586 Pathology

A 24-year-old woman with leukemia receives an allogeneic bone marrow transplant. Three weeks later, she develops a skin rash and diarrhea. Liver function tests show elevated serum levels of AST and ALT. A skin biopsy discloses a sparse lymphocytic infiltrate in the dermis and epidermis, as well as apoptotic cells in the epidermal basal cell layer. Skin rash and diarrhea in this patient are caused primarily by which of the following cells?

ADonor lymphocytes
BDonor plasma cells
CFixed tissue macrophages
DRecipient lymphocytes
Pathology
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1592 Pathology

A 50-year-old lady presented With a 3-month history of pain in the lower third of the right thigh. There was no local swelling; tenderness was present on deep pressure. Plain X-rays showed an ill-defined intra medullary lesion with blotchy calcification at the lower end of the right femoral diaphysis,possible enchondroma or chondrosarcoma.Sections showed a cailaginous tumor.Which of the following histological features (if seen)would be most helpful to differentiate the two tumours?

AFocal necrosis and lobulation
BTumor permeation between bone trabeculea at periphery
CExtensive myxoid change
DHigh cellularity
Pathology
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