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15316 Pathology

A 45-year-old woman complains of severe headaches and difficulty in swallowing. Over the past 6 months, she has noticed small, red lesions around her mouth as well as thickening of her skin. The patient has “stone facies” on physical examination. Which of the following antigens is the most common and most specific target of autoantibody in patients with this disease?

AC-ANCA (anti-proteinase-3)
BDouble-stranded DNA
CP-ANCA (anti-myeloperoxidase)
DScl-70 (anti-topoisomerase I)
Pathology
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15317 Pathology

A 28 year old female teacher is found to have a prolonged bleeding time and normal platelet count. She had a bleeding of “easy bleeding” with frequent bleeding of the gums, epistaxis, cutaneous bleeding and menorrhagia, further testing revealed a deficiency of Von willebrand factor. Which of the following thrombogenic processes involving platelets is most directly impaired?

AAdhesion
BAggregation
CFormation of fibrinogen bridges
DConformational change with activation of phospholipid surface
Pathology
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