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15130 Pathology

An 18-year-old man moves from sea level to an elevation of 2,400 m to train as a skier. The increased requirement for oxygen delivery to tissues at the higher elevation stimulates the synthesis of a renal hormone (erythropoietin), which targets hematopoietic stem cells in the bone marrow. Erythropoietin promotes the survival of early erythroid progenitor cells primarily through which of the following mechanisms?

AAltered cell-matrix adhesion
BDownregulation of p53
CEnhanced glucose uptake
DInhibition of apoptosis
Pathology
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