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15077 Pathology

A 25-year-old woman with amenorrhea has never had menarche. On physical examination, she is 145 cm (4 ft 9 in) tall. She has a webbed neck, a broad chest, and widely spaced nipples. Strong pulses are palpable in the upper extremities, but there are only weak pulses in the lower extremities. On abdominal MR imaging, her ovaries are small, elongated, and tubular. Which of the following karyotypes is she most likely to have?

A45, X/46, XX
B46, X, X (fra)
C47, XXY
D47, XXX
Pathology
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15078 Pathology

A 50-year-old woman presents with easy fatigability, a smooth sore tongue, numbness and tingling of the feet, and weakness of the legs. A complete blood count shows a megaloblastic anemia that is not reversed by folate therapy. Hemoglobin is 5.6 g/dL, WBC count is 5,100/mL, and platelets are 240,000/mL. This patient most likely has a deficiency of which of the following vitamins?

AVitamin B1 (thiamine)
BVitamin B2 (riboflavin)
CVitamin B12
DVitamin K
Pathology
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15084 Pathology

An 80-year-old woman presents with a 4-hour history of fever, shaking chills, and disorientation. Her blood pressure is 80/40 mm Hg. Physical examination shows diffuse purpura on her upper arms and chest. Blood cultures are positive for Gram-negative organism. Which of the following cytokines is primarily involved in the pathogenesis of direct vascular injury in this patient with septic shock?

AInterferon-g
BTransforming Growth Factor-b (TGFb)
CPlatelet-derived growth factor
DTumor necrosis factor-a
Pathology
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