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14321 Pathology

An 11-year-old girl becomes infected with hepatitis A and experiences mild nausea for 1 week. On physical examination, she has minimal right upper quadrant tenderness and scleral icterus. Laboratory findings include a serum AST of 68 U/L, ALT of 75 U/L, and total bilirubin of 5.1 mg/dL. Her laboratory findings most likely result from which of the following changes in her hepatocytes?

ACell membrane defects
BLysosomal autophagy
CMitochondrial swelling
DNuclear chromatin clumping
Pathology
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14322 Pathology

Frozen section examination demonstrates fibrosis and cystic spaces. Also seen are areas of compressed glands with a lobular orientation. The glands are lined by a single layer of epithelial cells with oval nuclei and regular arrangement. No true invasion of glands into the adjacent stroma is seen. This patient probably has which of the following?

AAtypical ductal hyperplasia
BDuctal carcinoma in situ
CLobular carcinoma in situ
DSclerosing adenosis
Pathology
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