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13998 Pathology

A 58-year-old woman presents with a 2-month history of abdominal discomfort and dark stools. Physical examination shows pallor but no evidence of jaundice. Laboratory studies disclose a microcytic, hypochromic anemia, with a hemoglobin level of 6.7 g/dL. A barium swallow radiograph reveals a “leather bottle” appearance of the stomach. Microscopic examination shows diffusely infiltrating malignant cells, many of which are “signet ring” cells, in the stomach wall. Which of the following is the most likely diagnosis?

AFungating adenocarcinoma
BGastric leiomyosarcoma
CGastric lymphoma
DLinitis plastica
Pathology
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14004 Pathology

A 33-year-old woman discovers a lump in her left breast on self-examination. Her mother and sister both had breast cancer. A mammogram demonstrates an ill-defined density in the outer quadrant of the left breast, with microcalcifications. Needle aspiration reveals the presence of malignant, ductal epithelial cells. Genetic screening identifies a mutation in BRCA1. In addition to cell cycle control, BRCA1 protein promotes which of the following cellular functions?

AApoptosis
BCell Adhesion
CDNA Repair
DGene Transcription
Pathology
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