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13727 Pathology

A 26-year-old woman with a 6-month history of depression accompanied by active suicidal ideation ingests 35 g of acetaminophen. She quickly experiences nausea and vomiting. Within 1 day, she becomes progressively obtunded. On physical examination, her temperature is 36.9deg C, pulse is 75/min, respirations are 15/min, and blood pressure is 100/65 mm Hg. She is treated with N-acetylcysteine. Depletion of which of the following is most likely to accentuate her organ damage?

AGlutathione (GSH)
BAmylase
CCreatine kinase
DKetone bodies
Pathology
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13733 Pathology

A one year old boy presented withhepatosplenomegaly and delayed milestones. Theliver biopsy and bone marrow biopsy revealedpresence of histiocytes with PAS-positive Diastaseresistantmaterial in the cytoplasm. Electronmicroscopicexamination of these histiocytes is mostlikely to reveal the presence of;

ABirbeck granules in the cytoplasm
BMyelin figures in the cytoplasm
CParallel rays of tubular structures in lysosomes
DElectron dense deposit in the mitochondria
Pathology
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