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13367 Pathology

A 50-year-old woman develops a sudden, severe headache and is taken to the emergency department. On examination, she has nuchal rigidity. Her blood pressure is 115/83 mm Hg. A lumbar puncture is done; the CSF shows numerous RBCs, no neutrophils, a few mononuclear cells, and a normal glucose level. The Gram stain result is negative. CT imaging shows subarachnoid hemorrhage at the base of the brain. Which of the following vascular events has most likely occurred in this woman?

ABleeding from cerebral amyloid angiopathy
BHematoma formation from arteriolosclerosis
CMiddle cerebral artery thromboembolism
DRupture of an intracranial berry aneurysm
Pathology
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13368 Pathology

A 36-year-old, alcoholic woman presents with a 1-week history of yellow skin and sclerae. She has suffered persistent headaches. Her vital signs are normal. Physical examination reveals jaundice. Laboratory studies disclose markedly elevated levels of AST and ALT (956 and 1,400 U/L, respectively). A few days later, she develops hepatic encephalopathy and renal failure. A liver biopsy shows prominent centrilobular necrosis. Which of the following is the most likely diagnosis?

AAcetaminophen toxicity
BFatty liver of pregnancy
CMetastatic carcinoma
DReye syndrome
Pathology
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