Mcq Subject: Pathology
A 48 year old woman was admitted with a history of weakness for two months. On examination, cervical lymph nodes were found enlarged and spleen was palpable 2 cm below the costal margin. Her hemoglobin was 10.5 g/dl, platelet count 2.7 X 1091 L and total leukocyte count 40 X 109/ L, which included 80% mature lymphoid cells with coarse clumped chromatin. Bone marrow revealed a nodular lymphoid infiltrate. The peripheral blood lymphoid cells were positive for CD 19, CD5, CD20 and CD23 and were negative for CD 79 B and FMC-7. The histopathological examination of the lymph node in this patient will most likely exhibit effacement of lymph node arachitecture by –
A. A pseudofollicular pattern with proliferation centers
B. A monomorphic lymphoid proliferation with a nodular pattern
C. A predominantly follicular pattern
D. A diffuse proliferation of medium to large lymphoid cells with high mitotic rate
View DescriptionBrown atrophy occurs due to deposition of?
A. Melanin
B. Hemosiderin
C. Hematin
D. Lipofuscin
View DescriptionParoxysmal nocturnal hemoglobinuria (PNH) is a disease that results from defects in:
A. Ankyrin
B. Band 3
C. Spectrin
D. GPI
View DescriptionE-cadherin mutation is seen in metastasis of which type of breast carcinoma
A. Infiltrative ductal Ca
B. Lobular Ca
C. Metaplastic Ca
D. Medullary Ca
View DescriptionSecondary (AA) amyloid is seen in all except ?
A. RA
B. TB
C. Multiple myeloma
D. RCC
View DescriptionA 45 yr old woman has increasing abdominal girth for the past 2 years. On physical examination, She has abdominal distension. CT scan shows multiple nodules on peritoneal surfaces along with low attenuation mucinous ascites. Cytological examination was done after doing paracentesis. It showed well differentiated columnar cells with minimal nuclear atypia. From which sit did this pathology start?
A. Pancreas
B. Ileum
C. Jejunum
D. Appendix
View DescriptionAll of the following act as cell adhesion molecules, EXCEPT:
A. Integrin
B. Selectin
C. Cadherin
D. Lecithin
View DescriptionThe most common cause of TMJ ankylosis is:
A. Trauma
B. Osteoarthritis
C. Childhood illness
D. Rheumatoid arthritis
View DescriptionWhich of the following is not a benign tumor?
A. Lipoma
B. Leiomyoma
C. Hepatoma
D. Chondroma
View DescriptionAn IV drug abuser develops an aggressive form of nephrotic syndrome that does not respond to steroids. A renal biopsy is performed. Which of the following histological diagnoses will most likely be made from the biopsy tissue?
A. Focal segmental glomerulosclerosis
B. IgA nephropathy
C. Membranous glomerulonephritis
D. Membranoproliferative glomerulonephritis
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