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12898 Pathology

A 22-year-old woman presents with painless cervical lymphadenopathy, night sweats, and generalized pruritus. An enlarged cervical lymph node is removed for diagnosis. On cut surface, it shows broads bands of fibrosis. Histologically, the affected lymph node contains a mixture of cells, including lymphocytes, histiocytes, eosinophils, plasma cells, and scattered large cells with prominent nucleoli. Which of the following is the most likely condition?

ACat-scratch disease
BHodgkin disease
CReactive non-specific lymphadenitis
DNon-Hodgkin lymphoma
Pathology
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12900 Pathology

A 12-year-old boy has a cough and earache for the past 2 days. He has a history of recurrent infections, including otitis media, diarrhea, and pneumonia. Physical examination shows an erythematous right tympanic membrane, a cleft palate, and murmur suggestive of congenital heart disease. A thoracic CT scan shows a small thymus. Results of laboratory studies suggest mild hypoparathyroidism. Which of the following diagnostic studies is most likely to be helpful in diagnosing this patient’s condition?

AAdenosine deaminase assay in lymphocytes
BBranched DNA assay for HIV-1 RNA level
CFISH analysis with a probe for chromosome 22q11.2
DLymph node biopsy
Pathology
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