Mcq Subject: Pathology

All of the following molecules/enzymes may contribute in generating free oxygen radicals within neutrophils for killing intracellular bacteria, except-

A. Nitric oxide

B. Fenton's reaction

C. NADPH oxidase

D. Catalase

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Perforin ?

A. NK cell

B. Cytotoxic T cell

C. Plasma cell

D. Monocyte

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A 54 year old man presents to a physician with headaches. A complete blood count demonstrates a hematocrit of 62%. The peripheral smear showed normocellular erythrocytes, with increased reticulocytes and nucleated red cells. Bone marrow biopsy demonstrates increased numbers of erythrocytic precursors. Cancer of which of the following organs would be most likely to cause these findings?

A. Colon

B. Kidney

C. Ovary

D. Prostate

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Proto-Oncogene associated with Familial Medullary thyroid carcinoma is

A. KRAS

B. BRAF

C. RET

D. KIT

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Macrophages are found in:

A. Phase of scar formation

B. Phase of repair

C. Late phase of inflammation

D. Early phase of inflammation

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Which of the following is responsible for respiratory burst and production of superoxide ions-

A. Hydrolase

B. Catalase

C. Peroxidase

D. NADPH oxidase

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A 36-year-old woman presents with a 6-month history of progressive generalized itching, weight loss, fatigue, and yellow sclerae. She denies use of oral contraceptives or any other medication. Physical examination reveals mild jaundice and steatorrhea. Blood studies show a high cholesterol level of 350 mg/dL, elevated serum alkaline phosphatase (240 U/L), and normal levels of AST and ALT. An intravenous cholangiogram shows no evidence of obstruction. An antimitochondrial antibody test is positive; antinuclear antibodies are not present. For the patient, a liver biopsy would most likely show which of the following pathologic findings?

A. Central hyaline sclerosis

B. Cholangiocarcinoma

C. Hemosiderosis

D. Intrahepatic bile duct damage

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Not true regarding fresh frozen plasma –

A. Supplies major coagulation factors

B. ABO match not required

C. Should be used in replacement of factors in DIC/trauma

D. To be used within 30 minutes of having trauma

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Serum C3 is persistently low in the following except –

A. Post-streptococcal glomerulonephritis

B. Membranoproliferative glomerulonephritis

C. Lupus nephritis

D. GlomerulonePhritis related to bacterial endocarditis

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Most common cause of cervical neoplasia is

A. HPV 6

B. HPV 11

C. HPV 16

D. HPV36

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