Mcq Subject: Pathology

A 2-year-old girl with a history of chronic constipation since birth is brought to the emergency room because of nausea and vomiting. Physical examination shows marked abdominal distension. Abdominal radiography reveals distended bowel loops with a paucity of air in the rectum. A rectal biopsy shows an absence of ganglion cells. Which of the following is the most likely diagnosis?

A. Acquired megacolon

B. Anorectal stenosis

C. Hirschsprung disease

D. Imperforate anus

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In apoptosis which is/are involved –

A. Apaf-1

B. Bc12

C. Caspases

D. All

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Primary biliary cirrhosis is most commonly associated with______

A. Systemic sclerosis

B. Sjogren syndrome

C. Ulcerative colitis

D. Pancreatitis

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A 90-year-old woman with mild diabetes and Alzheimer disease dies in her sleep. At autopsy, hepatocytes are noted to contain golden cytoplasmic granules that do not stain with Prussian blue. Which of the following best accounts for pigment accumulation in the liver of this patient?

A. Advanced age

B. Alzheimer disease

C. Congestive heart failure

D. Diabetic ketoacidosis

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All are factors of poor wound healing except –

A. Young age

B. Infection

C. Zinc deficiency

D. Vitamin D deficiency

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Platelet adhesion to vessel wall is due to?

A. Factor IX

B. Fibrinogen

C. vWF

D. Fibronectin

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Phagocytosis is the function of-

A. Astrocytes

B. Oligodendrocytes

C. Microglia

D. Schawan cells

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Marker of small cell cancer of lung is –

A. Chromogranin

B. Cytokeratin

C. Vimentin

D. Desmin

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A 17-year-old boy comes to the physician because of edema of both legs as well as pen- orbital edema There is no history of diarrhea and no urinary symptoms suggestive of infection. He had a throat infection 3 weeks ago. His blood pressure is 110/70 mmHg. He undergoes a kidney biopsy and light microscopy is normal. The patient is treated and makes a full recovery. Which of the following is the most likely diagnosis?

A. Accelerated hypertension

B. ANCA associated vasculitis

C. Minimal change glomerulonephnitis

D. Post-streptococcal glomerulonephritis

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Atypical pneumonia can be caused by the following microbial agents except ?

A. Mycoplasma pneumoniae

B. Legionella peumophila

C. Human corona virus

D. Klebsiella pneumoniae

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