Mcq Subject: Pathology

A 34-year-old man complains of sudden attacks of dizziness, blurred vision, and excruciating headaches of 4 months in duration. During one of these attacks, his blood pressure was 180/120 mm Hg. The patient’s father had been treated for thyroid cancer about 15 years ago. Laboratory studies show normal serum levels of aldosterone, renin, and angiotensin. A 24-hour urinalysis reveals increased metanephrines. Episodic hypertension in this patient is most likely caused by a tumor in which of the following endocrine organs?

A. Adrenal

B. Kidney

C. Parathyroid

D. Pituitary

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Earliest feature of TB:-

A. Granuloma

B. Langerhan's Giant cells

C. Lymphocytosis

D. Caseation

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Tau proteins are most commonly associated with –

A. Alzheimer's disease

B. Alcoholism

C. Tuberculosis

D. Meningitis

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A 45 year old male patient complains of fever, weakness and loss of appetite. General physical examination reveals splenomegaly. Histopathologic examination reveals LAP score of 10. This patient may be suffering from?

A. Thrombocytosis

B. Polycythemia vera

C. Chronic myeloid leukemia

D. Myelofibrosis

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A 25 year-old man from New Jersy after a fight incurs blunt trauma to his upper outer arm. On physical examination, there is a 2 x 3 cm contusion. He bleeds but the initial soft tissue bleeding stops in a few minutes and the size of the bruise does not increase. Which of the following chemical mediators is most impoant in this episode of hemostasis?

A. Prostaglandin

B. Prostacyclin

C. Plasminogen

D. Thromboxane

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Mutation of STK II / LKB I gene results in

A. Peutz Jegher's syndrome

B. Cowden syndrome

C. Familial adenomatous polyposis

D. HNPCC

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Kinky hair disease is a disorder where an affected child has peculiar white stubby hair, does not grow, brain degeneration is seen and dies by age of two years. Mrs A is hesitant about having children because her two sisters had sons who had died form kinky hair disease. Her mother’s brother also died of the same condition. Which of the following is the possible mode of inheritance in her family –

A. X-linked recessive

B. X-linked dominant

C. Autosomal recessive

D. Autosomal dominant

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Pseudo-Pelger-Huet cells or seen in

A. Hairy cell leukemia

B. Multiple myeloma

C. Mylodysplastic syndrome

D. Hodgkin's lymphoma

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Libmann sacks endocarditis is associated with?

A. SLE

B. NBTE

C. Rheumatic

D. Fungal

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A 56-year-old woman with a history of hyperlipidemia and hypeension develops progressive, right renal aery stenosis. Over time, this patient’s right kidney is likely to demonstrate which of the following morphologic adaptations to paial ischaemia?

A. Atrophy

B. Dysplasia

C. Hyperplasia

D. Hyperophy

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