Mcq Subject: Pathology

All of the following are not false about cytokines, except:

A. Include interleukins

B. Produced only in sepsis

C. Cytokines are polypeptides

D. Can have paracrine action

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What is the formula for lytic complex in complement system?

A. C5a

B. C5-9

C. C3b

D. C3a

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The mutation in cystic fibrosis is on which chromosome ?

A. 7p

B. 7q

C. 5p

D. 5q

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Which of the following disease show fibrinoid necrosis?

A. Tuberculosis

B. Vasculitis

C. Abscess

D. Pancreatitis

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A characteristic histologic feature of class IV lupus nephritis is

A. "Holly leaf" mesangial deposits

B. "Spike and dome" appearance of the basement membrane

C. "Wire-loop" appearance of the glomerular capillaries

D. "Tram-track" splitting of the basement membrane

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All of the following statements are true related to histamine, except:

A. Histamine is a principal mediator of immediate transient response during acute inflammation.

B. It causes dilation of aerioles

C. It increases the permeability of venules

D. Histamine receptor agonists are used to treat allergies.

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Which one of the following statements about Hemoglobin S (HbS) is not true –

A. Hemoglobin HbS differs from hemoglobin HbA by the substitution of Val for Glu in position 6 of the beta chain

B. One altered peptide of HbS migrates faster towards the cathode (-) than the corresponding peptide of HbA

C. Binding of HbS to the deoxygenated HbA can extend the polymer and cause sickling of the red blood cells

D. Lowering the concentration of deoxygenated HbS can prevent sickling

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Which of the following is associated with anti-glomerular basement membrane antibody ?

A. IgA nephropathy

B. Membranous glomerulonephritis

C. Goodpasture's syndrome

D. Membrano-proliferative glomerulonephritis

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A newborn baby presented with a failure to pass meconium in the immediate postnatal period. The pediatrician also notices visible yet ineffective peristalsis, and abdominal distention. A radiological contrast enema demonstrated a narrow conical segment and a dilated proximal bowel. A diagnosis of Hirschsprung disease was made. Which of the following is a cause of the condition in the patient?

A. Failure of migration of neural crest cells

B. Excessive peristalsis of the affected pa of gut

C. Failure of involution of vitelline duct

D. Obstruction secondary to an infectious agent

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Prader-Wili syndrome includes the following except-

A. Congenital hypotonia

B. Obesity and hyperphagia

C. Mental retardation

D. Cafe-au lait spots

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