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11504 Pathology

A 31-year-old woman has experienced increasing malaise for the past 4 months. Physical examination yields no remarkable findings. Laboratory studies show total serum protein of 6.4 g/dL, albumin of 3.6 g/dL, total bilirubin of 1.4 mg/dL, AST of 67 U/L, ALT of 91 U/L, and alkaline phosphatase of 99 U/L. Results of serologic testing for HAV, HBV, and HCV are negative. Test results for ANA, anti-liver kidney microsome-1 and anti-smooth muscle antibody are positive. A liver biopsy is done; microscopically, there are minimal portal mononuclear cell infiltrates with minimal interface hepatitis and mild portal fibrosis. What is the most likely diagnosis?

Aa1-Antitrypsin deficiency
BAutoimmune hepatitis
CChronic alcoholism
DHDV infection
Pathology
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11508 Pathology

Waterhouse-Friderichsen Syndrome is

AAdrenal failure due to rapid withdrawal of steroids
BMassive adrenal hemorrhage following difficult delivery in neonates.
CMassive adrenal hemorrhage following disseminated bacterial infection
DAdrenal crisis in individuals with chronic adrenocoical insufficiency precipitated by any form of stress
Pathology
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