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11102 Pathology

A 21-year-old woman incurs a blow to her head from a fall while mountain biking. She then has loss of consciousness for 5 minutes. On examination her deep tendon reflexes are diminished. A head CT scan 6 hours later shows no abnormalities. She recovers over the next week, with no neurologic deficits, but cannot remember this event. During the next year she has irritability, headache, difficulty sleeping, trouble concentrating, and fatigue. Which of the following is the most likely consequence from her injury?

AArteriolosclerosis
BConcussion
CHydrocephalus
DLeukoencephalopathy
Pathology
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11104 Pathology

A 2-year-old boy has had almost continuous infections since he was 6 months old. These infections have included otitis media, pneumonia, and impetigo. Organisms cultured include Haemophilus influenzae, Streptococcus pneumoniae, and Staphylococcus aureus. He also has had diarrhea, with Giardia lamblia cysts identified in stool specimens. The family history indicates that an older brother with a similar condition died because of overwhelming infections. The boy’s two sisters and both parents are not affected. Which of the following laboratory findings would most likely be seen in this boy?

AAbsence of IgA
BAgammaglobulinemia
CDecreased complement C3
DHigh titer of HIV-1 RNA
Pathology
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