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10946 Pathology

A 68-year-old man from Birmingham, England, has had “heartburn” and substernal pain after meals for 25 years. For the past year, he has had increased pain with difficulty swallowing both liquids and solids. On physical examination, there are no remarkable findings. Upper gastrointestinal endoscopy shows an ulcerated lower esophageal mass that nearly occludes the lumen of the esophagus. A biopsy specimen of this mass is most likely to show which of the following neoplasms?

AAdenocarcinoma
BCarcinoid tumor
CLeiomyosarcoma
DNon-Hodgkin lymphoma
Pathology
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10947 Pathology

A 72-year-old woman with long history of type-2 DM presents with abdominal pain. Physical examination reveals neuromuscular weakness and hypeension. Laboratory studies show markedly reduced serum calcium and elevated PTH. A surgical exploration of the patient’s neck demonstrates 4 symmetrically enlarged parathyroid glands. This patient’s endocrinopathy may be caused by which of the following underlying disorders?

AAdrenal insufficiency
BChronic liver disease
CInsulin deficiency
DRenal insufficiency
Pathology
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