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10648 Pathology

A 42 -year old man was referred with a 2 week history of fever weakness and bleeding gum. Peripherial smear showed pancytopenia. The bone marrow examinationrevelaed 26% blasts frequently exhibiting Auer rods andmature myeloid cells. An occasional neutrophil withpseudo Pelger-Huet anomaly was also noted : Which ofthe following cytocheimcal stains is most likely to bepositive ?

AAcid phosphatase
BNon specific esterase.
CMyeloperoxidase
DToluidine blue.
Pathology
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10651 Pathology

An 11-year-old boy had a sore throat, no cough, tonsillar exudates, and 38.3deg C fever 3 weeks ago, and a throat culture was positive for group A b-hemolytic Streptococcus. On the follow-up examination, the child is afebrile. His pulse is 85/min, respirations are 18/min, and blood pressure is 90/50 mm Hg. On auscultation, a diastolic mitral murmur is audible, and there are diffuse rales over both lungs. Over the next 2 days, he has several episodes of atrial fibrillation accompanied by signs of acute left ventricular failure. Which of the following pathologic changes occurring in this child’s heart is most likely to be the cause of the left ventricular failure?

AAmyloidosis
BFibrinous pericarditis
CMitral valve fibrosis
DMyocarditis
Pathology
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10653 Pathology

A one year old boy presented with hepatosplenomegaly and delayed milestones. The liver biopsy and bone marrow biopsy revealed presence of histiocytes with PAS-positive Diastase-resistant material in the cytoplasm. Electron-microscopic examination of these histiocytes is most likely to reveal the presence of –

ABirbeck granules in the cytoplasm
BMyelin figures in the cytoplasm
CParallel rays of tubular structures in lysosomes
DElectron dense deposit in the mitochondria
Pathology
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