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10290 Pathology

A 23-year-old man undergoing chemotherapy for acute lymphoblastic leukemia has developed a fever and abdominal pain within the past week. He now has a severe cough. On physical examination, his temperature is 38.4deg C. On auscultation, crackles are heard over all lung fields. Laboratory studies show hemoglobin, 12.8 g/dL; hematocrit, 39%; MCV, 90 mm3; platelet count, 221,000/mm3; and WBC count, 16,475/mm3 with 51% segmented neutrophils, 5% bands, 18% lymphocytes, 8% monocytes, and 18% eosinophils. Infection with which of the following organisms is most likely to be complicating the course of this patient’s disease?

ACryptococcus neoformans
BCytomegalovirus
CPseudomonas aeruginosa
DStrongyloides stercoralis
Pathology
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10291 Pathology

In a study of patients with non-Hodgkin B cell lymphoma, a nuclear gene is found to be actively transcribed to mRNA and is transported into the cell cytoplasm. A protein is translated from this mRNA, with up-regulation of BCL2. In a control group without lymphoma, translation of the mRNA does not occur. How is the silencing of this active gene’s mRNA most likely to occur?

AAbsence of tRNA
BBinding to miRNA
CMethylation of DNA
DMutation of mRNA
Pathology
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