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10103 Pathology

A 65-year-old man has developed pruritus followed by blistering skin lesions over the trunk, legs, and arms over the past month. On physical examination, there are 1- to 4-cm tense bullae, particularly over flexural surfaces of the skin. A biopsy of one lesion is examined microscopically by direct immunofluorescence staining and shows a subepidermal bulla, with both IgG and C3 deposited linearly along the dermal-epidermal junction. He is treated with topical corticosteroids, and a month later the lesions are healed without scarring. Which of the following components of the skin has most likely been targeted by an autoantibody in this man?

AHemidesmosome
BKeratinocyte cell membrane
CLamina densa
DNucleus
Pathology
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10105 Pathology

A 49 year old female presents with a non-healing ulcer on the right medial malleolus. On examination, there is symmetrical loss of sensation in both the extremities. She also complained of a recurrent white discharge from her vagina. Her menstrual cycles are irregular. She is complaining of hot flashes lately. The most likely pathological finding to be seen in the peripheral nerves is

AAxonal neuropathy
BAcute inflammation
CWallerian degeneration
DLymphocytic infiltration in the endoneurium
Pathology
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