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10022 Pathology

A 10 year old male, although mentally retarded, is able to carry out activities of daily living, including feeding and dressing himself.On physical examination, he has branchycephaly and oblique palpebral fissures with prominent epicanthal folds. On the palm of each hand is seen a transverse crease. On auscultation of the chest, there is a grade III/IV systolic murmur. Which of the following diseases will be most likely have by the age of 20 –

AAcute leukemia
BHepatic cirrhosis
CChronic renal failure
DAcute myocardial infarction
Pathology
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10025 Pathology

A 53-year-old woman discovers a lump in her breast and physical examination confirms a mass in the lower, outer quadrant of the left breast. Mammography demonstrates an ill-defined, stellate density measuring 1 cm. Needle aspiration reveals malignant ductal epithelial cells. A modified radical mastectomy is performed. The surgical specimen reveals a firm irregular mass (arrows). Which of the following cellular markers would be the most useful to evaluate before considering therapeutic options for this patient?

ACollagenase
BEstrogen receptors
CGalactosyltransferase
DLysosomal acid hydrolases
Pathology
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