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9386 Pathology

A 75-year-old woman has experienced increasing dull but constant pain in the back, right chest, left shoulder and left upper thigh for the past 6 months. She has now developed a sudden, severe, sharp pain in the left thigh. On physical examination, she has intense pain on palpation of the upper thigh, and the left leg is shorter than the right. A radiograph of the left leg shows a fracture through the upper diaphyseal region of the femur in a 5-cm lytic area that extends through the entire thickness of the bone. A bone scan shows multiple areas of increased uptake in the left femur, pelvis, vertebrae, right third and fourth ribs, upper left humerus, and left scapula. Laboratory studies show serum creatinine, 0.9 mg/ dL; total protein, 6.7 g/dL; albumin, 4.5 g/dL; total bilirubin, 1 mg/dL; AST, 28 U/L; ALT, 22 U/L; and alkaline phosphatase, 202 U/L. What is the most likely diagnosis?

AHyperparathyroidism
BMetastatic carcinoma
CMultiple myeloma
DOsteochondromatosis
Pathology
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9387 Pathology

True about apoptosis is all, EXCEPT

AConsiderable apoptosis may occur in tissues before it becomes apparent in histology
BApoptosis of cells induce inflammatory reaction
CApoptotic cells appear round mass of the intensely eosinophilic cytoplasm with dense nuclear chromatin fragments
DMacrophages phagocytose the apoptotic cells and degrade them.
Pathology
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