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894 Pathology

A 42-year old man was referred with a 2 week history of fever weakness and bleeding gum. Peripheral smear showed pancytopenia. The bone marrow examination revealed 26% blasts frequency exhibiting Auer rods and mature myeloid cells. An occasional neutrophil with pseudo Pelger-Huet anomaly was also detected. Which of the following cytochemical stains is most likely to be positive?

AAcid phosphatase
BNon-specific esterase
CMyeloperoxidase
DToluidine blue
Pathology
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896 Pathology

A 27-year-old man and his 24-year-old wife have been trying to conceive a child for 6 years. Physical examination shows he has bilateral gynecomastia, reduced testicular size, reduced body hair, and increased length between the soles of his feet and the pubic bone. A semen analysis indicates oligospermia. Laboratory studies show increased follicle-stimulating hormone level and slightly decreased testosterone level. Which of the following karyotypes is this man most likely to have?

A46, X, I (Xq)
B47, XYY
C47, XXY
D46, XX/47, XX, +21
Pathology
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