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1146 Microbiology

A sexually active woman was seen for a routine gynecologic exam that included a Pap smear. The report indicated cervical intraepithelial neoplasia. In situ hybridization showed the presence of human papillomavirus (HPV) type 16 genomes within the neoplastic cells. Which of the following processes is required for HPV to lead to the development of cancer?

AIntegration of the viral genome
BLoss of HPV E6 and E7 genes
CMutation of the virus
DViral replication
Microbiology
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