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10945 Microbiology

A thirty year man presented with nausea, fever and jaundice of 5 days duration. The biochemical tests revealed a bilirubin of 6.7 mg/dl (conjugated 5.0 mg/dl) with SGOT/SGPT (AST/ALT) of 1230/ 900 IU/ml. The serological tests showed presence of HBsAg, IgM anti HBc and HBe Ag. The most likely diagnosis –

AChronic hepatitis B infection with high infectivity
BAcute hepatitis B infection with high infectivity
CChronic hepatitis B infection with low infectivity
DAcute hepatitis B infection with low infectivity
Microbiology
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10952 Microbiology

A 12 year old boy has a productive cough characterized by large volumes of foul-smelling sputum. Three years ago, the patient was diagnosed with pancreatic insufficiency, as evidenced by repetitive gastrointestinal symptoms of steatorrhea. After culture of the sputum, colorless, oxidase-positive colonies with a fruity aroma develop on the agar. The function of which of the following proteins is most likely inhibited by the bacteria responsible for this boy’s infection?

AA CFTR protein lacking a phenylalanine in exon 10 at position 508
BA GTP-binding protein involved in the elongation step of protein synthesis
CA GTP-binding protein similar to the one coupled with & alpha 2-adrenergic receptors
DA GTP-binding protein similar to the one coupled with & beta-adrenergic receptors
Microbiology
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