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A 12 months old girl of Punjabi parents developed pallor since 3 months of age. One unit of blood transfusion was done at 5 months of age. Now presents with pallor, on examination hepatosplenomegaly. Hemoglobin was 3.8 gm/dl, MCV= 68, MCH = 19. Peripheral smear showed schistocytes. Bone marrow examination show erythroid hyperplasia. Diagnosis is:

ASickle cell anemia
BAlpha-thalassemia
CBeta-thalassemia (major)
DGlucose-6-phosphate dehydrogenase
Medicine
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