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6938 Medicine

A 48 year of woman was admitted with a history of weakness for two months. On examination cervical lymph nodes were found enlarged and spleen was palpable 2 cm below the costal margin. Her hemoglobin was 10.5 g/dl. platelet count 237 x 109/L, and total leukocyte count 40 x 109/L, which include 80% mature lymphoid cell with coarse clumped chromatin. Bone marrow revealed a nodular lymphoid infiltrate. The peripheral blood lymphoid cells were positive for CD19, CD5, CD20 and were negative for CD79B and FMC(-7). Which one of the following statements in not true about this disease?

ATrisomy 12 correlates an aggressive clinical course
BAbnormalities of 13q 14 are associated with long term survival
CCase with 11q22-23 deletions have excessive lymphadenopathy
Dt (11;14) translocation is present in most of the cases
Medicine
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6939 Medicine

An 18-year-old woman has a low hemoglobin value of 10.5 g/dL on routine CBC testing. The red cells are microcytic, but the WBC and platelet counts are normal. She has an adequate intake of iron-containing foods, her menstrual flow is normal, and there is no other history of blood loss. Her physical examination is completely normal, and iron studies reveal a normal ferritin level. She states that other members in her family have also been told they are anemic and given a diagnosis of alpha-thalassemia. Formation of which of the following hemoglobin’s is increased in alpha-thalassemia?

AH
BA
CF
DA2
Medicine
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