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4415 Medicine

A 29-year-old woman was found to have a hemoglobin of 7.8 g/dl. with a reticulocyte count of 0.8%. The peripheral blood smear showed microcytic hypochromic anemia, Hemoglobin A2 and hemoglobin F levels were 2.4% and 1.3% respectively. The serum iron and the total iron binding capacity were 15 micro g/dl, and 420 micro g/dl, respectively. The most likely cause of anemia is –

AIron deficiency anemia
BBeta-thalassemia minor
CSideroblastic anemia
DAnemia due to chronic infection
Medicine
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4419 Medicine

A 48 years of woman was admitted with a history of weakness for two months. On examination cervical lymph nodes were found enlarged and spleen was palpable 2 cm below the costal margin. Her hemoglobin was 10.5g/di. Platelet count 237x 109/L, and total leukocyte count 40×109/L, which include 80% mature lymphoid cell with coarse clumped chromatin. Bone marrow revealed dnodular lymphoid infiltrate. The peripheral blood lymphoid cells were positive for CD19, CD5, CD20 and were negative for CD79B and FMC(-7). Which one of the following statements is not true about this disease?

ATrisomy 12 correlates an aggressive clinical course
BAbnormalities of 13q 14 are associated with long term survival
CCase with 11q22-23 deletions have excessive lymphadenopathy
Dt(11;14) translocation is present in most of the cases
Medicine
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