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2472 Medicine

A 38-year-old man presents with involuntary facial grimacing, shrugging of the shoulders, and jerking movements of the limb. His father was similarly affected. There is also a history of mood changes for the past 3 months. On examination, he appears restless with intermittent slow movements of his hands and face. He has difficulty performing rapid finger movements, and tone is decreased in the upper and lower limbs. Which of the following is most likely to represent the progression of his illness?

Aa normal life span
Ba 50% chance of only male children being similarly affected
Cmental deterioration
Deventual development of rigidity
Medicine
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2473 Medicine

An 18-year-old boy presents with digital gangrene in third and fourth fingers for last 2 weeks. On examination the blood pressure is 170/110 mm of Hg and all peripheral pulses were palpable. food and urine examinations were unremarkable.Antinuclear antibodies, antibody to double stranded NA and antineutrophil cytoplasmic antibody were negative. The most likely diagnosis is :

AWegener's granulomatosis
BPolyarteritis nodosa
CTakayasu's arteritis
DSystemic lupus erythematosus (SLE)
Medicine
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