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2062 Medicine

A patient who is being treated for temporal lobe epilepsy (complex paial seizures) and who is having recurrent seizures on his chronic regimen of carbamazepine is given phenobarbital as a second drug. However, the seizures increase in frequency. What is the probable reason for the apparent deleterious effect of adding phenobarbital:

AIntracerebral bleeding from worsening bone marrow suppression
BDecreased carbamazepine level
CDecreased stability of CNS neuronal membranes
DHypokalemia
Medicine
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