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17156 Medicine

After using transdermal nitroglycerin skin patches for 1 week, a patient with an 8-month history of chronic stable angina pectoris observes an increasing frequency of mild angina episodes during exeion. The patient has been conscientiously applying a new patch every morning immediately after removing the old one. The patient’s increased frequency of anginal attacks is most likely because of

AA sudden onset of vasospastic angina
BEngaging in vigorous exercise
CCellular tolerance to organic nitrates
DInduction of cytochrome P450 enzyme by nitroglycerin
Medicine
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