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16821 Medicine

A 45-year-old woman has pain in her fingers on exposure to cold, arthralgias, and difficulty swallowing solid food. She has a few telangiectasias over the chest but no erythema of the face or extensor surfaces. There is slight thickening of the skin over the hands, arms, and torso. What is the best diagnostic workup?

ARheumatoid factor and anti-CCP antibodies
BAntinuclear, anti-Scl-70, and anticentromere antibodies
CCreatine kinase (CK) and antisynthetase antibodies (such as anti-Jo-1)
DBUN and creatinine
Medicine
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