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A four year old boy was admitted with a history of abdominal pain and fever for two months, maculopapular rash for ten days, and dry cough, dyspnea and wheezing for three days. On examination, liver and spleen were enlarged 4 cm and 3 cm respectively below the costal margins. His hemoglobin was 10.0 g/dl, platelet count 37 x 109/L and total leukocyte count 70 x 109/L, which included 80% eosinophils. Bone marrow examination revealed a cellular marrow comprising 45% blasts and 34% eosinophils and eosinophilic precursors. The blasts stained negative for myeloperoxidase and nonspecific esterase and were positive for CD19, CDIO, CD22 and CD20. Which one of the following statements in not true about this disease?

AEosinophils are not pa of the Neoplastic clone
Bt(5:14) rearrangement may be detected in blasts
CPeripheral blood eosinophilia may normalize with chemotherapy
DInv (16) is often detected in the blasts and the eosinophils.
Medicine
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