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14393 Medicine

A 21 year old male presented with sho stature & lack of secondary sexual characteristics. He has been operated for brain tumor 12 years ago & underwent cranial radiation. Which of the following is true regarding acquired hypopituitarism due to radiation?

AAt a dose of 50 Gy of radiation, only 5% of patients will manifest hypopituitarism.
BThe majority of patients who develop hypopituitarism after cranial radiation, do so within a year of treatment.
CGrowth hormone is the most common hormonal deficiency.
DOlder adults are at highest risk from radiation-induced hypopituitarism.
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14395 Medicine

A 62-year-old man presents to the office for assessment of symptoms of shortness of breath. The symptoms are worse with exertion and he notes difficulty lying down. He reports no chest pain or palpitations but his feet are swollen. His past medical history includes hypertension and type 2 diabetes, for which he is taking ramipril, amlodipine, and metformin.On physical examination, the blood pressure is 125/84 mm Hg, heart rate is 100/min. The jugular venous pressure is 8 cm above the sternal angle, with a third heart sound, pedal edema, and bibasilar crackles on auscultation of the lungs. Which one of the following may be implicated in fluid retention for this condition?

Adecreased renin
Bincreased aldosterone
Cincreased estrogen
Dincreased growth hormone
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