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7538 Biochemistry

Acetyl CoA is generated primarily in mitochondria. However, fatty acid synthesis from acetyl CoA occurs extramitochondrial (in the cytosol). By which one of the following mechanisms does acetyl CoA leave the mitochondrion and enter the cytosol?

AThe acetyl group is transferred to carnitine to form acetyl carnitine, which is transpoed across the inner mitochondrial membrane to the cytosol where it reacts with CoA to regenerate acetyl CoA
BAcetyl CoA condenses with oxaloacetate to form citrate, which is transpoed into the cytosol where it is cleaved to generate acetyl CoA and oxaloacetate in an ATP-dependent reaction
CAcetyl CoA reacts with carbon dioxide to form malonyl CoA, which is transpoed across the mitochondrial membrane
DThe mitochondrial membrane permits permeation of acetyl CoA by active transpo
Biochemistry
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