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469 Biochemistry

The common feature of Nuclear Localization Signals is

AThey are rich in acidic amino acid residues and are located at the C-terminus of the protein
BThey are rich in basic amino acid residues and are located at the C-terminus of the protein
CThey are rich in acidic amino acid residues and may be located anywhere in the protein sequence
DThey are rich in basic amino acid residues and may be located anywhere in the protein sequence (Correct Answer)
474 Biochemistry

A 68-year-old patient developed atrophic gastritis and, 2 years later, developed a macrocytic, hyperchromic anemia. His anemia has most likely occurred due to which one of the following reasons?

AThe atrophic gastritis leads to vitamin B12 malabsorption. (Correct Answer)
BThe atrophic gastritis raises the pH in the duodenum, leading to folate malabsorption.
CThe terminal ileum is also involved, so iron is malabsorbed.
DThe atrophic gastritis leads to increased red blood cell absorption by the spleen.