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3116 Biochemistry

A 48 year old male patient comes to the clinic for routine general checkup. He is a known diabetic and is on insulin. On general examination, truncal obesity is seen. The agent used in the treatment of this patient has all the following actions except:

AIt inhibits the release of FFA from adipose tissue
BIt enhances the uptake of glucose into adipose cells via the GLUT4 transporter
CIn adipose tissue, it inhibits the activity of hormone-sensitive lipase
DAdipose tissue is less sensitive to it than many other tissues
Biochemistry
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3122 Biochemistry

A 28-year-old man was found to have elevated cholesterol levels of 325 mg/dL on a routine checkup. His father died of a hea attack at the age of 42, and also had markedly elevated cholesterol levels throughout his life. The man’s physician placed him on lovastatin, and his cholesterol levels dropped to 170 mg/dL. The nature of the elevated cholesterol in this patient is most likely due to a mutation in which one of the following proteins?

AMicrosomal triglyceride transfer protein
BLCAT
CLipoprotein lipase
DLDL receptor
Biochemistry
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